The role of Porphyromonas gingivalis in severe periodontal disease.
Porphyromonas gingivalis (Pg) is a keystone pathogen with strong links to severe periodontal disease. Found deep in the tooth root pocket, together with other bacteria, Pg is believed to disrupt the homeostasis of the oral microbiome, triggering chronic inflammation.
Pathogenic Pg deep in the pocket multiple and release microbial toxins that cause gum inflammation and bleeding. The blood acts as a food source for Pg (and other bacteria), helping them to multiply. Pg microbial toxins make it difficult for your immune system to control the growth of Pg.
The inflammation caused by Pg and the microbial toxins it secretes, eventually destroys the tooth ligaments and the bone of the tooth socket unless successfully treated.